RELION

REgularised LIkelihood OptimisatioN


Synopsis

Empirical Bayesian approach to refinement of 3D reconstructions or 2D class averages in CryoEM

Description

RELION (for REgularised LIkelihood OptimisatioN, pronounce rely-on) is a stand-alone computer program that employs an empirical Bayesian approach to refinement of (multiple) 3D reconstructions or 2D class averages in electron cryo-microscopy (cryo-EM). It is developed in the group of Sjors Scheres at the MRC Laboratory of Molecular Biology. Briefly, the ill-posed problem of 3D-reconstruction is regularized by incorporating prior knowledge: the fact that macromolecular structures are smooth, i.e. they have limited power in the Fourier domain. In the corresponding Bayesian framework, many parameters of a statistical model are learned from the data, which leads to objective and high-quality results without the need for user expertise. 

URL

https://www2.mrc-lmb.cam.ac.uk/relion/index.php?title=Main_Page

Versions

NMRbox Version Software Version
3.0.0 2.0.3-1,

Keywords

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